13th Edition of the International
«Levures, Modèles et Outils»
Conference

11-14 September, 2018

Musikinsel, Rheinau

Early registration is recommended as the number of participant is limited.

The LMO meeting series was created in the early 1990’s to foster scientific exchanges between French-speaking yeast researchers. However, due to its great success, it has now adopted an English format to accommodate yeast researchers from around the globe.

Although inconspicuous, yeast are extremely important to our daily lives. They make the bread we eat, and the beer and wine we drink. However, yeast, and other fungi, also have a dark side in that they cause opportunistic infections, or mycoses, which can range in severity from mild, e.g. skin rashes, to deadly, like fungal pneumonia. Mycoses are often very challenging to treat - the reason for this lies in the fact that fungi, like us, are eukaryote organisms; and, therefore, share with our own cells very similar biochemical processes. This means that drugs that are toxic to yeast are also often toxic to us. On the bright side, this also means that studies that shed light on the basic molecular biology of yeast have direct relevance to the understanding of how our own cells function. Said another way, yeast which are relatively simple, inexpensive to grow, unencumbered with ethical concerns, and, possess unsurpassed genetic accessibility, remain a fantastic model with which we can probe our own molecular origins. To evidence this conclusion one needs look no further than the 2016 Nobel prize in physiology or medicine , awarded to Yoshinori Ohsumi who, using yeast, discovered the basic mechanisms for autophagy; or, to the 2017 Albert Lasker Basic Medical Research Award to Mike Hall, who, again with yeast, revealed that nutrient-activated Target Of Rapamycin (TOR) proteins regulate cell growth in all eukaryotes. This latter prize is especially poignant for Swiss science as Mike Hall's TOR work was conducted at the Biozentrum in Basel. What better way to celebrate this, and other yeast-based successes, than to host the 13th edition of the Levures Modèles et Outils meeting in Switzerland?

As a backdrop to this « celebration » we have chosen the beautiful village of Rheinau, on the Swiss/German border. The conference itself will be held in a recently renovated monastery. Our logic for choosing this unique location was two-fold. Firstly, all meeting participants will be housed together, enabling us to passively implement informal discussions outside of formal presentation sessions. Secondly, this stunning setting, situated in the middle of the Rhine river, contributed to our ability to attract ten distinguished, international (USA, UK, and Europe) yeast researchers from across Europe and the United States. These speakers will share their recent discoveries concerning how yeast, and by extension all eukaryotes, regulate growth and metabolism. Specifically, presenters will narrate the state-of-the-art understanding of fundamental mechanisms governing cell polarity, DNA repair and gene expression, protein and membrane homeostasis, metabolism, and longevity.

Programme

TuesdaySeptember 11, 2018
15:00 – 17:00Registration and Welcome
17:00 – 17:10Opening address (Claudio de Virgilio)
Session 1Chair: Claudio de Virgilio
17:10 – 17:40
Robbie Loewith
17:40 – 17:55Rafael Lucena Cell Size and Growth Rate Are Modulated by TORC2-Dependent Signals
17:55 – 18:10Margot Riggi Decrease in Plasma Membrane Tension Triggers PtdIns(4,5)P2 Phase Separation to Inactivate TORC2
18:10 – 18:25Franck Van Drogen External and intrinsic mechanical stress restricts pheromone signaling by Pkc1 dependent phosphorylation of MAPK scaffold Ste5
18:00 – 19:00Flash talks, "My project in 180 seconds"

Rasha Khaddaj Mature lipid droplets are accessible to endoplasmic reticulum luminal proteins
Deniz Irvali Metabolic Control of the Cell Cycle
Elie Saliba Further evidence for the signaling capability of the yeast H+-ATPase Pma1 in TORC1 stimulation
Pedro Carpio Malia A link between TORC1 and vacuole membrane homeostasis during osmotic stress
Isabelle Georis Amino acid excretion in yeast: tool development and search for the transporters involved
Daniela Smogrovicova Free and immobilised brewer’s yeast in stress conditions
Heena Shoket Novel role of YDR131C in Glycerol and MMS stress response
Fabian Schlottmann Mechanisms of Phototoxicity
Christophe Jacob The use of S. cerevisiae as a toolbox for understanding how modular polyketide synthases function

19:30 – 22:00Dinner
WednesdaySeptember 12, 2018
Session 2Chair: Christian Ungermann
08:30 – 09:00
Fulvio Reggiori
09:00 – 09:15Takeshi Noda Vacuolar protein Tag1 is involved in autophagy termination
09:15 – 09:30Yu-San Yang Yeast Ataxin-2 condensates regulate TORC1 activity and autophagy
09:30 – 09:45Hagai Abeliovich The role of mitochondrial matrix protein phosphorylation in the regulation of mitophagic selectivity
09:45 – 10:00Oliver Schmidt post-ER organelle associated degradation (pERAD) of trans-membrane proteins at cytosolic proteasomes
10:00 – 10:30Coffee break
Session 3Chair: Jared Rutter
10:30 – 11:00
Benjamin Tu
11:00 – 11:15Jennifer Ewald The cell cycle phospho-proteome under nutrient limitation
11:15 – 11:30Sriram Varahan A metabolic basis of spatial organization and the emergence of division of labor within an isogenic microbial community.
11:30 – 12:00Flash talks, "My project in 180 seconds"

Dimitris Liakopoulos Control of spindle function by SUMO-targeted Ubiquitin Ligases
Alfonso Fernandez Alvarez Spindle assembly without spindle pole bodies in fission yeast meiosis
Laura Merlini A system of two GTPases regulates positive feedbacks for cell polarity in fission yeast
Aleksandar Vjestica Meiotic cell cycle and re-fertilization blocks are coordinately regulated in fission yeast
Bruno Charpentier Structure-function analysis of the box C/D snoRNP assembly factor Bcd1p
Mathieu Rederstorff Synthetic lethality between U3 snoRNA and Rrp9 protein mutants sheds new light on the role of Rrp9 for U3/pre-ribosomal RNA interaction and pre-ribosomal RNA processing
Jing Hou Independent modifier origins underlying conditional gene essentiality across yeast natural populations
Sadri Znaidi Systematic Gene Overexpression in C. albicans identifies a Regulator of Early Adaptation to the Mammalian Gut

12:15 – 13:15Lunch buffet
Session 4Chair: Benjamin Tu
13:45 – 14:15
Jared Rutter
14:15 – 14:30Markus Babst Eisosomes are Metabolically Regulated Storage Compartments for APC-type Nutrient Transporters
14:30 – 14:45Vikram Panse Puf6 directs correct RNA folding during ribosome assembly
14:45 – 15:00David Shore A regulatory system involving the Hsf1 and Ifh1 transcription factors monitors ribosome biogenesis and promotes ribosomal protein homeostasis
15:00 – 15:15Martine Collart Co-translational assembly of proteasome subunits in Not1–containing assemblysomes
15:15 – 15:30Antonella Ruggiero Investigating the role of protein phosphatase 1 in promoting mitotic slippage
15:30 – 16:00Coffee break
Session 5Chair: Joao Matos
16:00 – 16:30
Jim Haber
16:30 – 16:45Rita Cha Essential function of Mec1, the budding yeast ATM/ATR checkpoint-response kinase, in protein homeostasis
16:45 – 17:00Stefano Mattarocci Rif1's odyssey around telomeres to control DNA replication
17:00 – 17:15Matthias Peter From Yeast to Beer
17:15 – 18:15Poster session 1
19:00 – Dinner
ThursdaySeptember 13, 2018
Session 6Chair: Jürg Bähler
08:30 – 09:00
Christian Ungermann
09:00 – 09:15Riko Hatakeyama Spatially sequestered pools of TORC1 target distinct effectors
09:15 – 09:30Svetlana Dokudovskaya The SEA complex maintains vacuole-mitochondria contact sites and controls mitophagy
09:30 – 09:45Stephanie Cottier Tracking lipid droplet fate during yeast mating
09:45 – 10:15Coffee break
Session 7Chair: Sophie Martin
10:15 – 10:45
Jürg Bähler
10:45 – 11:00Agnès Michel Functional Mapping Of Yeast Genomes By Saturated Transposition
11:00 – 11:15André Verdel RNA-based gene regulation in fission yeast
11:15 – 11:30Adnane Sellam Systematic genetic analysis in the opportunistic yeast C. albicans reveals evolutionary plasticity of cell size homeostasis mechanisms in eukaryotes
11:30 – 11:45Coffee break
Session 8Chair: Jolanda van Leeuwen
11:45 – 12:15
Sophie Martin
12:15 – 12:30Andrea Picco The contributions of the actin machinery to endocytic membrane bending and vesicle formation
12:30 – 12:45Serge Pelet Dynamic single cell analysis of a cell fate decision system
12:45 – 13:45Lunch buffet
13:45 – 14:45Poster session 2
Session 9Chair: David Shore
15:00 – 15:30
Joao Matos
15:30 – 15:45Dom Helmlinger Principles of assembly of the SAGA transcriptional co-activator complex
15:45 – 16:00Ozge Uysal Ozdemir Generation and analysis of conditional mutants of the S. pombe SIN regulator etd1p
16:00 – 16:30Coffee break
Session 10Chair: Françoise Stutz
16:30 – 17:00
Jolanda van Leeuwen
17:00 – 17:15Elodie Caudal Systematic characterization of background specific essential genomic regions in yeast
17:15 – 17:45Poster prize award (Don Helmlinger)
17:45 – 18:00Closing remarks (Matthias Peter)
19:00 – BBQ in the barn
FridaySeptember 14, 2018
Departure

Invited Speakers

Venue

Musikinsel
8462 Rheinau
How to get there
venue situation More about the venue...

Registration

The registration fee varies depending on the type of room chosen. It also includes all meals, coffee breaks and a BBQ on the final evening..

Abstract submission deadline has been extended to August 1st, 2018.
Shared room typeRegistration fee
Double550 CHF
Sextuple510 CHF
Octuple500 CHF
Persons wishing to attend during one or more days need to register with the organizers and pay a fee upon arrival of CHF 100.- per day.
All registrations will definitively close on Sept. 4, 2018

Register now

Sponsors

Microsynth logo Sunrise Science Product logo

Organization

Organizing Committee

  • Claudio DE VIRGILIO (UniFR)
  • Robbie LOEWITH (UniGe)
  • Matthias PETER (ETHZ)

Please contact us if you have any questions.

Scientific Committee

  • Isabelle GEORIS (IRMW, Bruxelles)
  • Dominique HELMLINGER (Montpellier)
  • Guilhem JANBON (Institut Pasteur, Paris)
  • Laurent KURAS (Gif)
  • Matthieu REDERSTORFF (Univ. Lorraine)
  • Joseph SCHACHERER (Strasbourg)
  • Marie Noelle SIMON (CNRS, Marseille)
  • Sadri ZNAIDI (Institut Pasteur, Tunis)

Previous editions

LMO 12 - April 13-15, 2016 in Brussels, Belgium
LMO 11 - April 07-09, 2014 in Bordeaux, France
LMO 10 - April 02-04, 2012 in Toulouse, France
LMO 09 - August 30 - September 02, 2010 in Strasbourg, France
LMO 08 - October 26-29, 2010 in La Colle sur Loup, France
LMO 07 - 2006 in Paris, France
LMO 06 - 2003 in Genève, Switzerland
LMO 05 - 2001 in Brussels, Belgium
LMO 04 - 1998 in Arcachon, France
LMO 03 - 1996 in Strasbourg, France
LMO 02 - 1993 in Gif-sur-Yvette, France
LMO 01 - 28-29 Mars, 1991, in Paris, France